Week 7 Post 1

 Video 1
-pharmacokinetics is study of relationship of plasma concentration over time
-ties into ADME from last week
-Plasma concentration is mass/vol
-IV bolus is is a drug that is directly injected into the bloodstream of a patient.
-as the drug is distributed through the body, the concentration goes down at a curve of exponential decay
-Cp 0 is a hypothetical number, because the blood will already begin to be distributed before the blood has completely circulated the body
-equation of graph is usually shown as
Cp=(Cp0)(e^(-kel)(t)
-ideal relationship for graph
-kel is elimination rate constant
-units of 1/time
-slope depends on concentration of drug itself
-elimination rate constant determines the half life of the drug
-half-life is (ln2)/(kel)
-to get it linear, it can be shown as ln(Cp)=-kel•t+ln(Cp0)
-kel=CL/Vd
-CL is clearance, which is volume of blood that contains a drug that is cleared per unit of time
-Vd is apparent volume of distribution
-Vd is a volume of drug that contains a drug

Video 2
-like a swimming pool, our body takes blood that has the drug in it and filters out the drug to return the blood back to the system
-bead and water demonstration

Video 3
-to calculate clearance, you need area under curve
-use the graph of Cp over time and ideal IV bolus
-AUC is area under the curve
-units are mass x time over volume
-AUC =Cp0/kel
-data doesn’t always fit under simple ideal relationship
-can use trapezoidal rule
-final area is based on last data point taken
-clearance is dose of drug used and that over the AUC

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