Week 8 Post 1

Video 1
-volume of distribution is the amount of of plasma needed to contain the drug in the body
-elimination constant determines half life
-one compartment model is when using an IV bolus the drug resides in the central compartment 
-central compartment defines some volume
-initial concentration of plasma is a hypothetical number
-Do is patient dose
-with this, one wants to find the volume of plasma and a mass of the drug to find concentration 
-volume using the equation Vd=do/cpo 
-this is how to find size of central compartment
-vol is more then 2.7L, bc 2.7 L is the amount of plasma a 70kg patient has
-vol of distribution is a hypothetical number
-it must be more so that the drug isn’t just in the bloodstream it’s going to the tissue 

Video 2
-two compartment model
-IV bolus puts drug into central compartment 
-drug can leave the central comparment and go to a different compartment called the peripheral compartment
-the peripheral compartment is anywhere that’s isn’t the main circulatory system
-kidneys and liver act on blood in the plasma not in tissues or in peripheral compartment 
-distribution is the move of the drug throughout the body
-full volume is both compartments
-mainly the elimination phase, measured  from both compartments
-terminal elimination rate is the slowest elimination pathway

Video 3
-oral drug
-After a small amount of time, the concentration rises as the drug is absorbed into the plasma
-the maximum conc occurs at Tmax
-time before tmax is the absorption phase
-after t Max is elimination phase
-study IV bolus before the oral, to already know about the drug

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