Week 9 Post 1

Video 1
-a challenge of oral drugs is maintaining a constant concentration in the body of drug
-keep the conc. above the minimum effected dose
-and below max tolerated dose
-these windows make the therapeutic window
-the graph is a repetition based on when you take your doses
-when taking oral doses, the concentration ocellates, but should never go about the max tolerated dose or below the effective dose
-make changes to dosing by frequency or by size of dose
-this can make it less convenient for the patient

Video 2
-an exciting lecture
-clearance=.693/t0.5*volume of distribution
-clearance is mL/min/Kg
-vd is L/kg
-half-life is the x in the y=mx+b
-8 hour half life is the goal
-to get the ideal half life of 8, you can change the Vd and CL
-lipophilic drugs tend to want to leave bloodstream more and boosts Vd

Video 3
-metabolism is actually two different ideas
-one is chatabolism
-the other is anabolism
-when talking about metabolism on drugs, drugs are not broken down for energy, or the molecules aren’t used to help make usurious nutrients
-we talk about xenobiotics, things that are synthetic and the liver breaks down and gets rid of
-diagram in video 8.1 halfway through
-two types of metabolism
-phase 1 metabolism is redoxes, and hydrolysis. Oxidation happens in the liver
-phase 2 metabolic
-take another molecule and make a larger molecule, more easily filtered by kidneys
-happens 1 then 2
-goal of metabolism is to filter drug out of the body

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